Hudson’s RapidHit™ Simultaneous Automated HitPicking System is a compact, self-contained system that allows users to obtain assay plates comprised of the actual hits detected in a primary screen using the same compound source plates that provided the primary screen. The RapidHit uses the output files produced by the plate reader as they become available, and automatically selects and transfers “hits” based on user-entered criteria. As each primary screen assay plate is finished, the RapidHit immediately moves the hits to a secondary assay “hit plate”, and completely eliminates the possibility of receiving the wrong compounds in secondary screening plates.
The RapidHit saves the need to return to the users compound storage library to run secondary or conformational screens of the hits in a primary screen. The hit-picked plates are prepared even while the primary screen is taking place, so the secondary or conformational screen can go forward without any delay. And, because the original source compound plates are being used, the secondary assay uses the same compound conditions as the primary screen. This eliminates any artifacts that may result from preparing secondary assay plates anew from the compound library.